Application of bifurcation theory and siRNA-based control signal to restore the proper response of cancer cells to DNA damage

DOI10.1016/j.jtbi.2016.08.017zbMath1352.92055OpenAlexW2513115469WikidataQ38751127 ScholiaQ38751127MaRDI QIDQ727152

Emilia Kozłowska, Krzysztof Puszynski

Publication date: 6 December 2016

Published in: Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1016/j.jtbi.2016.08.017

zbMATH Keywords

bifurcation theorysiRNAtransduction pathway

Mathematics Subject Classification ID

Medical applications (general) (92C50) Biochemistry, molecular biology (92C40) Cell biology (92C37)

Related Items (3)

Mathematical modelling of core regulatory mechanism in p53 protein that activates apoptotic switch ⋮ Mathematical analysis of a generalised p53-Mdm2 protein gene expression model ⋮ Codimension-3 Bifurcation in the p53 Regulatory Network Model

Cites Work

• Oscillations and bistability in the stochastic model of p53 regulation
• Regulation of p53 by siRNA in radiation treated cells: Simulation studies
• Elements of applied bifurcation theory

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