Neutrophil dynamics during concurrent chemotherapy and G-CSF administration: mathematical modelling guides dose optimisation to minimise neutropenia

DOI10.1016/j.jtbi.2015.08.015zbMath1343.92215OpenAlexW1239088256WikidataQ40568792 ScholiaQ40568792MaRDI QIDQ739757

Michael C. Mackey, Fahima Nekka, Jun Li, Morgan Craig, Jacques Bélair

Publication date: 19 August 2016

Published in: Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1016/j.jtbi.2015.08.015

zbMATH Keywords

myelopoeisispharmacokinetics/pharmacodynamicsphysiological mathematical modelling

Mathematics Subject Classification ID

Medical applications (general) (92C50) Developmental biology, pattern formation (92C15)

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Uses Software

• Matlab

Cites Work

• A mathematical model of granulopoiesis incorporating the negative feedback dynamics and kinetics of G-CSF/neutrophil binding and internalization
• Mathematical model for G-CSF administration after chemotherapy
• Neutrophil dynamics after chemotherapy and G-CSF: the role of pharmacokinetics in shaping the response
• Oscillations in cyclical neutropenia: new evidence based on mathematical modeling
• The complex effect of granulocyte colony-stimulating factor on human granulopoiesis analyzed by a new physiologically-based mathematical model
• Cost-effective G-CSF therapy strategies for cyclical neutropenia: mathematical modelling based hypotheses
• A mathematical model of hematopoiesis. II: Cyclical neutropenia
• Neutrophil dynamics in response to chemotherapy and G-CSF
• G-CSF control of neutrophils dynamics in the blood
• Multistability in an age-structured model of hematopoiesis: cyclical neutropenia