A multi-scale mathematical modeling framework to investigate anti-viral therapeutic opportunities in targeting HIV-1 accessory proteins

DOI10.1016/J.JTBI.2015.08.032zbMath1343.92174OpenAlexW1625086967WikidataQ36387986 ScholiaQ36387986MaRDI QIDQ739788

Gajendra W. Suryawanshi, Alexander Hoffmann

Publication date: 19 August 2016

Published in: Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL: https://escholarship.org/uc/item/42s7569v

zbMATH Keywords

age-structured modelscombination therapyhost restriction factorshypermutationsreproductive ratio

Mathematics Subject Classification ID

Medical applications (general) (92C50) Biochemistry, molecular biology (92C40)

Related Items (3)

Global dynamics of an age-space structured HIV/AIDS model with viral load-dependent infection and conversion rates ⋮ Mathematical analysis of an age-structured HIV-1 infection model with CTL immune response ⋮ Dynamical analysis and optimal control of an age-since infection HIV model at individuals and population levels

Cites Work

• Modeling HIV persistence, the latent reservoir, and viral blips
• An age-structured model of HIV infection that allows for variations in the production rate of viral particles and the death rate of productively infected cells
• A model for treatment strategy in the chemotherapy of AIDS
• Optimizing within-host viral fitness: infected cell lifespan and virion production rate
• Mathematical Modeling of HIV-1 Infection and Drug Therapy
• Mathematical Analysis of Age‐Structured HIV‐1 Dynamics with Combination Antiretroviral Therapy

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