Hypothalamus-pituitary-thyroid feedback control: implications of mathematical modeling and consequences for thyrotropin (TSH) and free thyroxine (FT4) reference ranges

DOI10.1007/S11538-014-9955-5zbMath1298.92026OpenAlexW2092632303WikidataQ48800153 ScholiaQ48800153MaRDI QIDQ742378

Simon L. Goede, Johannes W. Dietrich, Jan W. A. Smit, Melvin Khee-Shing Leow, Harald H. Klein

Publication date: 18 September 2014

Published in: Bulletin of Mathematical Biology (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1007/s11538-014-9955-5

zbMATH Keywords

control systemsloop gainhypothalamus-pituitary-thyroid axisreference rangeset point

Mathematics Subject Classification ID

Physiology (general) (92C30)

Related Items (1)

HIGH RESOLUTION FREE TRIIODOTHYRONINE-THYROTROPIN (FT3-TSH) RESPONSES TO A SINGLE ORAL DOSE OF LIOTHYRONINE IN HUMANS: EVIDENCE OF DISTINCT INTER-INDIVIDUAL DIFFERENCES UNRAVELED USING AN ELECTRICAL NETWORK MODEL

Uses Software

• Graph

Cites Work

• A mathematical model of pituitary-thyroid interaction to provide an insight into the nature of the thyrotropin-thyroid hormone relationship
• General error analysis in the relationship between free thyroxine and thyrotropin and its clinical relevance
• A novel minimal mathematical model of the hypothalamus-pituitary-thyroid axis validated for individualized clinical applications
• A computational model of the human thyroid
• A patient-specific model of the negative-feedback control of the hypothalamus-pituitary-thyroid (HPT) axis in autoimmune (Hashimoto's) thyroiditis

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