On the retention of gene duplicates prone to dominant deleterious mutations

DOI10.1016/j.tpb.2014.01.004zbMath1296.92160OpenAlexW2051520313WikidataQ34404465 ScholiaQ34404465MaRDI QIDQ743527

Param Priya Singh, Hervé Isambert, Giulia Malaguti

Publication date: 24 September 2014

Published in: Theoretical Population Biology (Search for Journal in Brave)

Full work available at URL: https://zenodo.org/record/895351

zbMATH Keywords

purifying selectiondominant deleterious mutationspopulation genetics modelssmall scale duplicationwhole-genome duplication

Mathematics Subject Classification ID

Population dynamics (general) (92D25) Genetics and epigenetics (92D10)

Uses Software

• PSI-BLAST
• BLAST
• UniProt
• GeneCards

Cites Work

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• A coalescent dual process in a Moran model with genic selection
• Role of selection in fixation of gene duplications
• The allele-frequency spectrum in a decoupled Moran model with mutation, drift, and directional selection, assuming small mutation rates
• A coalescent dual process in a Moran model with genic selection, and the lambda coalescent limit

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