Maximum-likelihood estimation of the statistical distribution of Smith- Waterman local sequence similarity scores

DOI10.1007/BF02458620zbMath0733.92013OpenAlexW4246726420WikidataQ47687649 ScholiaQ47687649MaRDI QIDQ810409

Richard Mott

Publication date: 1992

Published in: Bulletin of Mathematical Biology (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1007/bf02458620

zbMATH Keywords

DNAgapsmaximum-likelihood estimationSmith-Waterman algorithmprotein sequence similaritiesstatistical significance of sequence similarity scores

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Biochemistry, molecular biology (92C40) Protein sequences, DNA sequences (92D20)

Cites Work

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• An accurate approximation to the distribution of the length of the longest matching word between two random DNA sequences
• An extreme value theory for sequence matching
• Two moments suffice for Poisson approximations: The Chen-Stein method
• Methods for assessing the statistical significance of molecular sequence features by using general scoring schemes.
• Stochastic scrabble: large deviations for sequences with scores

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