The construction of optimal designs for dose-escalation studies

DOI10.1007/s11222-012-9356-2zbMath1325.62147OpenAlexW2025697549MaRDI QIDQ892451

Allan E. Clark, Linda M. Haines

Publication date: 19 November 2015

Published in: Statistics and Computing (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1007/s11222-012-9356-2

zbMATH Keywords

exchange algorithmscomplete enumeration\(A\)-, \(MV\)-, \(D\)- and \(E\)-optimal designsdose-escalation studies

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Optimal statistical designs (62K05)

Related Items (3)

Optimal approximate designs for comparison with control in dose-escalation studies ⋮ Algorithmic construction of optimal block designs for two-colour cDNA microarray experiments using the linear mixed effects model ⋮ Optimal designs for dose-escalation trials and individual allocations in cohorts

Uses Software

• GAUSS
• Mathematica
• R

Cites Work

• The optimal design of blocked and split-plot experiments
• The Coordinate-Exchange Algorithm for Constructing Exact Optimal Experimental Designs
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