Continual reassessment and related dose-finding designs

DOI10.1214/10-STS332zbMath1328.62594arXiv1011.6251WikidataQ30431500 ScholiaQ30431500MaRDI QIDQ903292

John O'Quigley, Mark Conaway

Publication date: 5 January 2016

Published in: Statistical Science (Search for Journal in Brave)

Full work available at URL: https://arxiv.org/abs/1011.6251

zbMATH Keywords

maximum likelihoodclinical trialBayesian methodsefficacydose-finding studiesmaximum tolerated dosecontinual reassessment methodtoxicitydose escalationmost successful dosephase 1 trialsphase 2 trials

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Bayesian problems; characterization of Bayes procedures (62C10) Medical applications (general) (92C50) Stochastic approximation (62L20)

Related Items (6)

Efficiency of bridging between related dose finding studies ⋮ A Bayesian adaptive dose-finding algorithm for balancing individual- and population-level ethics in Phase I clinical trials ⋮ A continual reassessment method without undue risk of toxicity ⋮ Stochastic approximation and modern model-based designs for dose-finding clinical trials ⋮ Adaptive clinical trial designs for phase I cancer studies ⋮ Unnamed Item

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