Population structure and cryptic relatedness in genetic association studies

DOI10.1214/09-STS307zbMath1329.62419arXiv1010.4681OpenAlexW1967529528WikidataQ57393113 ScholiaQ57393113MaRDI QIDQ908120

William Astle, David Joseph Balding

Publication date: 3 February 2016

Published in: Statistical Science (Search for Journal in Brave)

Full work available at URL: https://arxiv.org/abs/1010.4681

zbMATH Keywords

mixed modelkinshipascertainmentcomplex disease geneticscryptic relatednessgenomic control

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Genetics and epigenetics (92D10)

Related Items (14)

Effective sample size: quick estimation of the effect of related samples in genetic case-control association analyses ⋮ Estimation of Simultaneous Signals Using Absolute Inner Product with Applications to Integrative Genomics ⋮ Two robust tools for inference about causal effects with invalid instruments ⋮ Estimation of the Relatedness Coefficients from Biallelic Markers, Application in Plant Mating Designs ⋮ Sparse probit linear mixed model ⋮ Incorporating genetic heterogeneity in whole-genome regressions using interactions ⋮ Methodological issues in multistage genome-wide association studies ⋮ Efficient computation with a linear mixed model on large-scale data sets with applications to genetic studies ⋮ Refining genetically inferred relationships using treelet covariance smoothing ⋮ Bayes factors in the presence of population stratification ⋮ A parametric approach to kinship hypothesis testing using identity-by-descent parameters ⋮ The Blessings of Multiple Causes ⋮ Gene-Based Association Testing of Dichotomous Traits With Generalized Functional Linear Mixed Models Using Extended Pedigrees: Applications to Age-Related Macular Degeneration ⋮ Improving the efficiency of genomic selection

Uses Software

• PLINK
• STRUCTURE
• Eigenstrat
• GWAS Catalog

Cites Work

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• That BLUP is a good thing: The estimation of random effects. With comments and a rejoinder by the author
• Likelihood-based inference for genetic correlation coefficients
• Control of Population Stratification by Correlation-Selected Principal Components
• Impact of Population Substructure on Trend Tests for Genetic Case-Control Association Studies
• Logistic disease incidence models and case-control studies
• Genomic Control for Association Studies
• Equivalence of prospective and retrospective models in the Bayesian analysis of case-control studies
• Genomic Control for Association Studies under Various Genetic Models

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