Lessons from models of pancreatic \(\beta \) cells for engineering glucose-sensing cells

DOI10.1016/J.MBS.2010.05.005zbMath1194.92023OpenAlexW1994179349WikidataQ34054232 ScholiaQ34054232MaRDI QIDQ991520

Arthur S. Sherman

Publication date: 7 September 2010

Published in: Mathematical Biosciences (Search for Journal in Brave)

Full work available at URL: http://europepmc.org/articles/pmc2918698

zbMATH Keywords

oscillationsinsulindiabetescalciumsecretioncell engineering

Mathematics Subject Classification ID

Medical applications (general) (92C50) Physiology (general) (92C30) Cell biology (92C37)

Related Items (2)

Delay in ATP-dependent calcium inflow may affect insulin secretion from pancreatic beta-cell ⋮ Fast-slow analysis of the integrated oscillator model for pancreatic \(\beta\)-cells

Cites Work

• A calcium-based phantom bursting model for pancreatic islets
• Mathematical simulation of membrane processes and metabolic fluxes of the pancreatic \(\beta\)-cell
• A phantom bursting mechanism for episodic bursting
• Phantom bursting is highly sensitive to noise and unlikely to account for slow bursting in \(\beta\)-cells: considerations in favor of metabolically driven oscillations
• The Geometry of Bursting in the Dual Oscillator Model of Pancreatic $\beta$-cells

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