Statistical inference of transmission fidelity of DNA methylation patterns over somatic cell divisions in mammals

DOI10.1214/09-AOAS297zbMath1194.62112arXiv1011.2025OpenAlexW2952472435WikidataQ35010390 ScholiaQ35010390MaRDI QIDQ993262

Charles D. Laird, Matthew Stephens, Reinhard Stöger, Audrey Qiuyan Fu, Diane P. Genereux

Publication date: 10 September 2010

Published in: The Annals of Applied Statistics (Search for Journal in Brave)

Full work available at URL: https://arxiv.org/abs/1011.2025

zbMATH Keywords

stationaritymeasurement errorBayesian inferenceMarkov chain Monte Carlo (MCMC)hierarchical modelsDNA methylationmulti-site modelsepigeneticshairpin-bisulfite PCRtransmission fidelity

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Bayesian inference (62F15) Biochemistry, molecular biology (92C40) Cell biology (92C37) Genetics and epigenetics (92D10)

Related Items (2)

Bayesian inference supports a location and neighbour-dependent model of DNA methylation propagation at the MGMT gene promoter in lung tumours ⋮ Statistical inference of transmission fidelity of DNA methylation patterns over somatic cell divisions in mammals

Cites Work

• The fundamentals of modern statistical genetics
• Statistical inference of transmission fidelity of DNA methylation patterns over somatic cell divisions in mammals

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