strata.MaxCombo

CRANstrata.MaxComboMaRDI QIDQ5983497

Stratified Max-Combo Test

Yumeng Wang, Yuwen Liu

Last update: 16 July 2023

Copyright license: GNU General Public License, version 2.0

Software version identifier: 0.0.1

Description

Non-proportional hazard (NPH) is commonly observed in immuno-oncology studies, where the survival curves of the treatment and control groups show delayed separation. To properly account for NPH, several statistical methods have been developed. One such method is Max-Combo test, which is a straightforward and flexible hypothesis testing method that can simultaneously test for constant, early, middle, and late treatment effects. However, the majority of the Max-Combo test performed in clinical studies are unstratified, ignoring the important prognostic stratification factors. To fill this gap, we have developed an R package for stratified Max-Combo testing that accounts for stratified baseline factors. Our package explores various methods for calculating combined test statistics, estimating joint distributions, and determining the p-values.

This page was built for software: strata.MaxCombo