refineR
Reference Interval Estimation using Real-World Data
Christopher M Rank, Tatjana Ammer, Andre Schuetzenmeister
Last update: 14 November 2023
Copyright license: GNU General Public License
Software version identifier: 1.6.0, 1.0.0, 1.5.0, 1.5.1, 1.6.1
Indirect method for the estimation of reference intervals using Real-World Data ('RWD'). It takes routine measurements of diagnostic tests, containing pathological and non-pathological samples as input and uses sophisticated statistical methods to derive a model describing the distribution of the non-pathological samples. This distribution can then be used to derive reference intervals. Furthermore, the package offers functions for printing and plotting the results of the algorithm. See ?refineR for a more comprehensive description of the features. Version 1.0 of the algorithm is described in detail in 'Ammer et al. (2021)' <doi:10.1038/s41598-021-95301-2>. Additional guidance on the usage of the algorithm is given in 'Ammer et al. (2023)' <doi:10.1093/jalm/jfac101>.
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