The effect of the reproductive system on mutation load
type: Item
instance of: scholarly article
title: The effect of the reproductive system on mutation load
zbMATH Open document ID: 0642.92007
DOI: 10.1016/0040-5809(88)90015-9
author: Frederic A. Hopf
author: Richard E. Michod
author: Michael J. Sanderson
published in: Theoretical Population Biology
publication date: 1988-01-01T00:00:00Z
review text: \textit{J. B. S. Haldane}, Amer. Nat. 71, 337-349 (1937), argued that, in equilibrium populations, the effect of deleterious mutation on average fitness depends primarily on the mutation rate and is independent of the severity of the mutations. Specifically, the equilibrium population fitness is \(e^{-\mu_ H}\), where \(\mu_ H\) is the haploid genomic mutation rate. Here we extend Haldane's result to a variety of reproductive systems. Using an analysis based on the frequency of classes of individuals with a specified number of mutations, we show that Haldane's principle holds exactly for haploid sex, haploid apomixis, and facultative haploid sex. In the cases of diploid automixis with terminal fusion, diploid automixis with central fusion, and diploid selfing, Haldane' principle holds exactly for recessive mutations and approximately for mutations with some heterozygous effect. In the cases of K-ploid apomixis, diploid endomitosis, and haplodiploidy, we show that Haldane's principle holds exactly for recessive lethal mutations. In addition we extend Haldane's result to various mixtures of the above-mentioned reproductive systems.
Mathematics Subject Classification ID: 92D10
zbMATH DE Number: 4047484
zbMATH Keywords: equilibrium populations
zbMATH Keywords: average fitness
zbMATH Keywords: mutation rate
zbMATH Keywords: reproductive systems
zbMATH Keywords: Haldane's principle
zbMATH Keywords: haploid sex
zbMATH Keywords: haploid apomixis
zbMATH Keywords: diploid automixis
zbMATH Keywords: K-ploid apomixis
zbMATH Keywords: diploid endomitosis
zbMATH Keywords: haplodiploidy
Wikidata QID: Q68043321
MaRDI profile type: Publication
full work available at URL: 0040-5809(88)90015-9
OpenAlex ID: W2007348319
cites work: The accumulation of deleterious genes in a population - Muller's Ratchet
cites work: Q5766614
cites work: Q4076577
Recommended article: Mutation and epimutation load in haploid and diploid life forms
Recommended article: Mutation, Sexual Reproduction and Survival in Dynamic Environments
Recommended article: Mutation load and mutation-selection-balance in quantitative genetic traits
Recommended article: Mutation modification with multiplicative fertility selection
Recommended article: Mutation-selection balance and mixed mating with asexual reproduction
Recommended article: Mutation-selection balance in mixed mating populations
Recommended article: Q4309435
Recommended article: The effect of recurrent mutations on genetic diversity in a large population of varying size
Recommended article: On the modification of recombination with sex-dependent fitnesses and linkage
Recommended article: Recombination and the evolution of mutational robustness
description: scientific article; zbMATH DE number 4047484