Reduction of cytotoxicity to normal tissues by new regimens of cell-cycle phase-specific drugs
type: Item
instance of: scholarly article
title: Reduction of cytotoxicity to normal tissues by new regimens of cell-cycle phase-specific drugs
zbMATH Open document ID: 0655.92004
DOI: 10.1016/0025-5564(88)90002-8
author: R. Arnon
author: B. Schechter
author: Zvia Agur
published in: Mathematical Biosciences
publication date: 1988-01-01T00:00:00Z
review text: A new policy for minimizing cytotoxicity to normal tissues of cell-cycle phase-specific drugs is suggested. This policy is based on short drug pulses and on an integer relation between the period of drug application and the cell-cycle length of the host susceptible tissue. The new protocol is expected to be effective even if the cell-cycle parameters of the malignant population have the same mean as those of the host cells but their variance is larger, and as long as the variance in the duration of the drug pulse is not too large. Under these conditions protocols can be determined by the host temporal parameters alone. The method has been verified in vitro, treating a leukemic cell line with cytosine arabinoside (Ara-C).
Mathematics Subject Classification ID: 92C50
Mathematics Subject Classification ID: 92Cxx
zbMATH DE Number: 4070692
zbMATH Keywords: chemotherapy
zbMATH Keywords: minimizing cytotoxicity to normal tissues
zbMATH Keywords: cell-cycle phase-specific drugs
zbMATH Keywords: short drug pulses
zbMATH Keywords: period of drug application
zbMATH Keywords: cell-cycle length
zbMATH Keywords: leukemic cell line
zbMATH Keywords: cytosine arabinoside
MaRDI profile type: Publication
full work available at URL: 0025-5564(88)90002-8
OpenAlex ID: W2090180109
cites work: The effect of environmental disturbances on the dynamics of marine intertidal populations
cites work: Estimation and prediction of cell cycle specific effects of anticancer drugs
cites work: Mathematical model of cancer chemotherapy. Periodic schedules of phase- specific cytotoxic-agent administration increasing the selectivity of therapy
description: scientific article; zbMATH DE number 4070692