Optimal dynamic instability of microtubules
type: Item
instance of: scholarly article
title: Optimal dynamic instability of microtubules
zbMATH Open document ID: 0906.92015
author: Charles S. Peskin
published in: Documenta Mathematica
publication date: 1998-08-06T00:00:00Z
full work available at URL: https://eudml.org/doc/224095
full work available at URL: Peskin.MAN.html
review text: Summary: Microtubules are polymers that play many important structural and functional roles within biological cells, including the separation of newly replicated chromosomes into the daughter cells during cell division. In order to catch the chromosomes that they must transport, microtubules grow out of the centrosome in each of the daughter cells. For any particular microtubule, epochs of steady growth are punctuated by episodes of rapid decay; this is known as dynamic instability. It allows for multiple attempts on the part of each microtubule to hit the small target at the center of each chromosome known as the kinetochore, where the microtubule can attach and apply traction to the chromosome. The optimal design of dynamic instability is the subject of this paper.
Mathematics Subject Classification ID: 92C40
Mathematics Subject Classification ID: 92C05
Mathematics Subject Classification ID: 92C45
zbMATH DE Number: 1184400
zbMATH Keywords: polymerization
zbMATH Keywords: chromosomes
zbMATH Keywords: microtubules
zbMATH Keywords: dynamic instability
zbMATH Keywords: kinetochore
MaRDI profile type: Publication
description: scientific article; zbMATH DE number 1184400