The kinetics of enzyme systems involving activation of zymogens
type: Item
instance of: scholarly article
title: The kinetics of enzyme systems involving activation of zymogens
zbMATH Open document ID: 0776.92009
DOI: 10.1007/BF02460651
author: M. C. Manjabacas
author: Bent H. Havsteen
author: M. Garcia-Moreno
author: Edelmira Valero
author: R. Varon
published in: Bulletin of Mathematical Biology
publication date: 1993-05-16T00:00:00Z
review text: The present paper proposes a model and a theoretical basis for kinetic studies of zymogen activation which is sufficiently general to include mechanisms processing one or more steps of zymogen activation in addition to possible steps of activation, reversible or irreversible inhibition, or inactivation. The explicit kinetic equations for the time courses of the various species and products involved are obtained and proved to be applicable not only to enzyme systems of zymogen activation but also to more complex zymogen activation cascades such as activation of the blood clotting factors, fibrinolysis, zymogen activations overlapping with reversible and/or irreversible inhibitions.
Mathematics Subject Classification ID: 92C45
zbMATH DE Number: 168730
zbMATH Keywords: prothrombin
zbMATH Keywords: plasminogen
zbMATH Keywords: prohormone conversion
zbMATH Keywords: proinsulin-insulin reaction
zbMATH Keywords: angiotensinogen
zbMATH Keywords: angiotensin
zbMATH Keywords: immune system
zbMATH Keywords: control of glucose concentration
zbMATH Keywords: inhibition
zbMATH Keywords: inactivation
zbMATH Keywords: explicit kinetic equations
zbMATH Keywords: enzyme systems
zbMATH Keywords: zymogen activation cascades
zbMATH Keywords: blood clotting factors
zbMATH Keywords: fibrinolysis
Wikidata QID: Q52396831
MaRDI profile type: Publication
cites work: On the validity of the steady state assumption of enzyme kinetics
cites work: The Quasi-Steady-State Assumption: A Case Study in Perturbation
cites work: Transient phase kinetics of activation of human plasminogen
cites work: Kinetics of a general model for enzyme activation through a limited proteolysis
description: scientific article; zbMATH DE number 168730