An unbiased test for the bioequivalence problem
type: Item
instance of: scholarly article
title: An unbiased test for the bioequivalence problem
zbMATH Open document ID: 0905.62107
author: Lawrence Brown
author: J. T. Gene Hwang
author: Axel Munk
published in: The Annals of Statistics
publication date: 1998-05-25T00:00:00Z
review text: The authors treat the problem demonstrating bioequivalence of treatments. The standard two one-sided tests procedure for bioequivalence is biased, so they construct an unbiased \(\alpha\)-level test. Since, in the construction, the rejection region of the unbiased test contains that of the two one-sided tests procedure, it is seen that the unbiased test is uniformly more powerful than the \(\alpha\)-level two-sided test procedure. The construction is numerically complemented and also the critical region is illustrated.
Mathematics Subject Classification ID: 62P10
Mathematics Subject Classification ID: 62F03
zbMATH DE Number: 1138415
zbMATH Keywords: uniformly most powerful
zbMATH Keywords: pharmacokinetic parameters
zbMATH Keywords: two one-sided tests procedure
zbMATH Keywords: unbiased \(\alpha\)-level test
reviewed by: Masafumi Akahira
MaRDI profile type: Publication
full work available at URL: https://doi.org/10.1214/aos/1030741076
OpenAlex ID: W2072224605
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DOI: 10.1214/AOS/1030741076
description: scientific article; zbMATH DE number 1138415