Design and analysis of DNA microarray investigations.
type: Item
instance of: scholarly article
title: Design and analysis of DNA microarray investigations.
zbMATH Open document ID: 1039.92019
author: Richard Simon
author: Edward L. Korn
author: Lisa M. McShane
author: Michael D. Radmacher
author: George W. Wright
author: Yingdong Zhao
published in: Statistics for Biology and Health
publication date: 2004-02-01T00:00:00Z
full work available at URL: 2004HumGenomWit.pdf
review text: This book is concerned with methods of analyzing data obtained from DNA microarray experiments. It also describes what microarrays are and which problems arise when planning and carrying out microarray experiments. The book is written for biologists without a strong statistical background, and also for computer scientists and statisticians interested in being collaborators in studies utilizing microarrays. The focus is on concepts rather than on formulas; mathematical notation is kept to a minimum. Chapters: 1. Introduction; 2. DNA Microarray Technology; 3. Design of DNA Microarray Experiments; 4. Image Analysis; 5. Quality Control; 6. Array Normalization; 7. Class Comparison; 8. Class Prediction; 9. Class Discovery. Appendices: A. Basic Biology of Gene Expression; B. Description of Gene Expression Datasets Used as Examples; C. BRB-ArrayTools. Chapters 2 through 6 are concerned with different aspects of microarray technology. Chapters 7 through 9 address methods of comparison, prediction and discovery of classes to which the specimens belong, based on gene expression profiles obtained from microarray data. Appendix A contains basic facts about the biology of gene expression. Appendix B gives information about the datasets used as examples in the book. Appendix C describes BRB-ArrayTools, a software package designed for the analysis of microarray data.
reviewed by: Alexander Mitrophanov
Mathematics Subject Classification ID: 92C40
Mathematics Subject Classification ID: 92-02
zbMATH DE Number: 2035090
zbMATH Keywords: biostatistics
zbMATH Keywords: microarray data analysis
describes a project that uses: impute
MaRDI profile type: Publication
OpenAlex ID: W575683998
DOI: 10.1007/B97583
description: scientific article; zbMATH DE number 2035090