Game theory of tumor-stroma interactions in multiple myeloma: effect of nonlinear benefits
type: Item
instance of: scholarly article
title: Game theory of tumor-stroma interactions in multiple myeloma: effect of nonlinear benefits
zbMATH Open document ID: 1395.92086
author: Javad Salimi Sartakhti
author: Mohammad Hossein Manshaei
author: Marco Archetti
published in: Games
publication date: 2018-07-10T00:00:00Z
review text: Summary: Cancer cells and stromal cells often exchange growth factors with paracrine effects that promote cell growth: a form of cooperation that can be studied by evolutionary game theory. Previous models have assumed that interactions between cells are pairwise or that the benefit of a growth factor is a linear function of its concentration. Diffusible factors, however, affect multiple cells and generally have nonlinear effects, and these differences are known to have important consequences for evolutionary dynamics. Here, we study tumor-stroma paracrine signaling using a model with multiplayer collective interactions in which growth factors have nonlinear effects. We use multiple myeloma as an example, modelling interactions between malignant plasma cells, osteoblasts, and osteoclasts. Nonlinear benefits can lead to results not observed in linear models, including internal mixed stable equilibria and cyclical dynamics. Models with linear effects, therefore, do not lead to a meaningful characterization of the dynamics of tumor-stroma interactions. To understand the dynamics and the effect of therapies it is necessary to estimate the shape of the benefit functions experimentally and parametrize models based on these functions.
Mathematics Subject Classification ID: 92C50
Mathematics Subject Classification ID: 91A22
Mathematics Subject Classification ID: 92C37
zbMATH DE Number: 6901042
zbMATH Keywords: game theory
zbMATH Keywords: cancer
zbMATH Keywords: stroma
zbMATH Keywords: tumor microenvironment
zbMATH Keywords: nonlinear benefits
MaRDI profile type: Publication
full work available at URL: g9020032
OpenAlex ID: W2805685966
cites work: Evolutionary games with affine fitness functions: applications to cancer
cites work: Studying the emergence of invasiveness in tumours using game theory
cites work: Evolutionary dynamics of the Warburg effect: glycolysis as a collective action problem among cancer cells
cites work: MMP-TIMP interactions in cancer invasion: an evolutionary game-theoretical framework
cites work: Review: Game theory of public goods in one-shot social dilemmas without assortment
cites work: How to analyze models of nonlinear public goods
Wikidata QID: Q129762736
DOI: 10.3390/G9020032
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description: scientific article; zbMATH DE number 6901042