Mathematical modeling of the adaptive immune responses in the early stage of the HBV infection
type: Item
instance of: scholarly article
title: Mathematical modeling of the adaptive immune responses in the early stage of the HBV infection
zbMATH Open document ID: 1487.92008
DOI: 10.1155/2018/6710575
author: Karam Allali
author: Adil Meskaf
author: Abdessamad Tridane
published in: International Journal of Differential Equations
publication date: 2018-08-10T00:00:00Z
review text: Summary: The aim of this paper is to study the early stage of HBV infection and impact delay in the infection process on the adaptive immune response, which includes cytotoxic T-lymphocytes and antibodies. In this stage, the growth of the healthy hepatocyte cells is logistic while the growth of the infected ones is linear. To investigate the role of the treatment at this stage, we also consider two types of treatment: interferon-\(\alpha\) (IFN) and nucleoside analogues (NAs). To find the best strategy to use this treatment, an optimal control approach is developed to find the possibility of having a functional cure to HBV.
Mathematics Subject Classification ID: 92C60
Mathematics Subject Classification ID: 34K20
Mathematics Subject Classification ID: 34K35
Mathematics Subject Classification ID: 49K15
zbMATH DE Number: 6915959
Wikidata QID: Q56786950
MaRDI profile type: Publication
full work available at URL: https://doi.org/10.1155/2018/6710575
OpenAlex ID: W2786841993
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description: scientific article; zbMATH DE number 6915959