Modeling and simulation of VEGF receptors recruitment in angiogenesis
type: Item
instance of: scholarly article
title: Modeling and simulation of VEGF receptors recruitment in angiogenesis
zbMATH Open document ID: 1427.92004
DOI: 10.1155/2018/4705472
author: Xianqiang Yang
published in: Mathematical Problems in Engineering
publication date: 2019-02-08T00:00:00Z
review text: Summary: Angiogenesis, the process of new blood vessel formation from preexisting ones, plays a pivotal role in tumor growth. Vascular endothelial growth factor receptor-2 (VEGFR2) is the main proangiogenic tyrosine kinase receptor expressed by endothelial cells (ECs). VEGFR2 binds different ligands triggering vascular permeability and growth. VEGFR2-ligands accumulate in the extracellular matrix (ECM) and induce the polarization of ECs as well as the relocation of VEGFR2 in the basal cell membrane in contact with ECM. We propose here a multiphysical model to describe the dynamic of VEGFR2 on the plasma membrane. The governing equations for the relocation of VEGFR2 on the membrane stem from a rigorous thermodynamic setting, whereby strong simplifying assumptions are here taken and discussed. The multiphysics model is validated against experimental investigations.
Mathematics Subject Classification ID: 92-08
Mathematics Subject Classification ID: 92C42
Mathematics Subject Classification ID: 92C37
Mathematics Subject Classification ID: 92C50
zbMATH DE Number: 7019011
MaRDI profile type: Publication
full work available at URL: https://doi.org/10.1155/2018/4705472
OpenAlex ID: W2888331970
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Wikidata QID: Q129269343
description: scientific article; zbMATH DE number 7019011