The role of the innate immune system in oncolytic virotherapy
type: Item
instance of: scholarly article
title: The role of the innate immune system in oncolytic virotherapy
zbMATH Open document ID: 1409.92121
DOI: 10.1155/2017/6587258
author: Tuan Anh Phan
author: Jianjun Paul Tian
published in: Computational \& Mathematical Methods in Medicine
publication date: 2019-03-13T00:00:00Z
review text: Summary: The complexity of the immune responses is a major challenge in current virotherapy. This study incorporates the innate immune response into our basic model for virotherapy and investigates how the innate immunity affects the outcome of virotherapy. The viral therapeutic dynamics is largely determined by the viral burst size, relative innate immune killing rate, and relative innate immunity decay rate. The innate immunity may complicate virotherapy in the way of creating more equilibria when the viral burst size is not too big, while the dynamics is similar to the system without innate immunity when the viral burst size is big.
Mathematics Subject Classification ID: 92C50
Mathematics Subject Classification ID: 92C30
zbMATH DE Number: 7035643
zbMATH Keywords: immune system
zbMATH Keywords: oncolytic virotherapy
zbMATH Keywords: innate immunity
MaRDI profile type: Publication
full work available at URL: https://doi.org/10.1155/2017/6587258
OpenAlex ID: W2773251671
Wikidata QID: Q47548048
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DBLP publication ID: journals/cmmm/PhanT17
description: scientific article; zbMATH DE number 7035643