Methodology and application of adaptive and sequential approaches in contemporary clinical trials
type: Item
instance of: scholarly article
title: Methodology and application of adaptive and sequential approaches in contemporary clinical trials
zbMATH Open document ID: 1282.62230
DOI: 10.1155/2012/527351
author: Zhengjia Chen
author: Yichuan Zhao
author: Ye Cui
author: Jeanne Kowalski
published in: Journal of Probability and Statistics
publication date: 2013-01-09T00:00:00Z
review text: Summary: The clinical trial, a prospective study to evaluate the effect of interventions in humans under prespecified conditions, is a standard and integral part of modern medicine. Many adaptive and sequential approaches have been proposed for use in clinical trials to allow adaptations or modifications to aspects of a trial after its initiation without undermining the validity and integrity of the trial. The application of adaptive and sequential methods in clinical trials has significantly improved the flexibility, efficiency, therapeutic effect, and validity of trials. To further advance the performance of clinical trials and convey the progress of research on adaptive and sequential methods in clinical trial design, we review significant research that has explored novel adaptive and sequential approaches and their applications in Phase I, II, and III clinical trials and discuss future directions in this field of research.
Mathematics Subject Classification ID: 62P10
Mathematics Subject Classification ID: 62L05
Mathematics Subject Classification ID: 62F35
zbMATH DE Number: 6123618
Wikidata QID: Q58910970
describes a project that uses: BayesDA
MaRDI profile type: Publication
full work available at URL: https://doi.org/10.1155/2012/527351
OpenAlex ID: W2006128945
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description: scientific article; zbMATH DE number 6123618