Spectral analysis of dynamic PET studies: a review of 20 years of method developments and applications
type: Item
instance of: scholarly article
title: Spectral analysis of dynamic PET studies: a review of 20 years of method developments and applications
zbMATH Open document ID: 1423.92183
DOI: 10.1155/2016/7187541
author: Mattia Veronese
author: Gaia Rizzo
author: Alessandra Bertoldo
author: Federico E. Turkheimer
published in: Computational \& Mathematical Methods in Medicine
publication date: 2017-08-10T00:00:00Z
review text: Summary: In positron emission tomography (PET), spectral analysis (SA) allows the quantification of dynamic data by relating the radioactivity measured by the scanner in time to the underlying physiological processes of the system under investigation. Among the different approaches for the quantification of PET data, SA is based on the linear solution of the Laplace transform inversion whereas the measured arterial and tissue time-activity curves of a radiotracer are used to calculate the input response function of the tissue. In the recent years SA has been used with a large number of PET tracers in brain and nonbrain applications, demonstrating that it is a very flexible and robust method for PET data analysis. Differently from the most common PET quantification approaches that adopt standard nonlinear estimation of compartmental models or some linear simplifications, SA can be applied without defining any specific model configuration and has demonstrated very good sensitivity to the underlying kinetics. This characteristic makes it useful as an investigative tool especially for the analysis of novel PET tracers. The purpose of this work is to offer an overview of SA, to discuss advantages and limitations of the methodology, and to inform about its applications in the PET field.
Mathematics Subject Classification ID: 92C55
Mathematics Subject Classification ID: 92-02
zbMATH DE Number: 6759156
zbMATH Keywords: positron emission tomography
zbMATH Keywords: spectral analysis
Wikidata QID: Q39042001
MaRDI profile type: Publication
full work available at URL: https://doi.org/10.1155/2016/7187541
OpenAlex ID: W2560474854
description: scientific article; zbMATH DE number 6759156