In silico investigation into cellular mechanisms of cardiac alternans in myocardial ischemia
type: Item
instance of: scholarly article
title: In silico investigation into cellular mechanisms of cardiac alternans in myocardial ischemia
zbMATH Open document ID: 1423.92097
DOI: 10.1155/2016/4310634
author: Jiaqi Liu
author: Yinglan Gong
author: Ling Xia
author: Xiaopeng Zhao
published in: Computational \& Mathematical Methods in Medicine
publication date: 2017-08-10T00:00:00Z
review text: Summary: Myocardial ischemia is associated with pathophysiological conditions such as hyperkalemia, acidosis, and hypoxia. These physiological disorders may lead to changes on the functions of ionic channels, which in turn form the basis for cardiac alternans. In this paper, we investigated the roles of hyperkalemia and calcium handling components played in the genesis of alternans in ischemia at the cellular level by using computational simulations. The results show that hyperkalemic reduced cell excitability and delayed recovery from inactivation of depolarization currents. The inactivation time constant \(\tau_f\) of L-type calcium current (\(I_{\mathrm{CaL}}\)) increased obviously in hyperkalemia. One cycle length was not enough for \(I_{\mathrm{CaL}}\) to recover completely. Alternans developed as a result of \(I_{\mathrm{CaL}}\) responding to stimulation every other beat. Sarcoplasmic reticulum calcium-ATPase (SERCA2a) function decreased in ischemia. This change resulted in intracellular Ca (Ca\(_i\)) alternans of small magnitude. A strong Na\(^+\)-Ca\(^{2+}\) exchange current (\(I_{\mathrm{NCX}}\)) increased the magnitude of Ca\(_i\) alternans, leading to APD alternans through excitation-contraction coupling. Some alternated repolarization currents contributed to this repolarization alternans.
Mathematics Subject Classification ID: 92C50
Mathematics Subject Classification ID: 92C30
Mathematics Subject Classification ID: 92C37
zbMATH DE Number: 6759162
zbMATH Keywords: myocardial ischemia
zbMATH Keywords: cellular mechanisms of cardiac alternans
zbMATH Keywords: calcium current
MaRDI profile type: Publication
full work available at URL: https://doi.org/10.1155/2016/4310634
OpenAlex ID: W2565076951
Wikidata QID: Q37533803
cites work: A human ventricular cell model for investigation of cardiac arrhythmias under hyperkalaemic conditions
DBLP publication ID: journals/cmmm/LiuGXZ16
description: scientific article; zbMATH DE number 6759162