Towards the design of a patient-specific virtual tumour
type: Item
instance of: scholarly article
title: Towards the design of a patient-specific virtual tumour
zbMATH Open document ID: 1423.92078
DOI: 10.1155/2016/7851789
author: Flavien Caraguel
author: Anne-Cécile Lesart
author: François Estève
author: B. van der Sanden
author: A. Stéphanou
published in: Computational \& Mathematical Methods in Medicine
publication date: 2017-08-10T00:00:00Z
review text: Summary: The design of a patient-specific virtual tumour is an important step towards personalized medicine. However this requires to capture the description of many key events of tumour development, including angiogenesis, matrix remodelling, hypoxia, and cell state heterogeneity that will all influence the tumour growth kinetics and degree of tumour invasiveness. To that end, an integrated hybrid and multiscale approach has been developed based on data acquired on a preclinical mouse model as a proof of concept. Fluorescence imaging is exploited to build case-specific virtual tumours. Numerical simulations show that the virtual tumour matches the characteristics and spatiotemporal evolution of its real counterpart. We achieved this by combining image analysis and physiological modelling to accurately described the evolution of different tumour cases over a month. The development of such models is essential since a dedicated virtual tumour would be the perfect tool to identify the optimum therapeutic strategies that would make personalized medicine truly reachable and achievable.
Mathematics Subject Classification ID: 92C50
Mathematics Subject Classification ID: 92C37
zbMATH DE Number: 6759169
zbMATH Keywords: patient-specific virtual tumour design
zbMATH Keywords: tumour growth kinetics
zbMATH Keywords: tumour invasiveness
zbMATH Keywords: personalized medicine
Wikidata QID: Q30833610
MaRDI profile type: Publication
full work available at URL: https://doi.org/10.1155/2016/7851789
OpenAlex ID: W2561874937
cites work: A mathematical model for pancreatic cancer growth and treatments
cites work: A multilayer grow-or-go model for GBM: effects of invasive cells and anti-angiogenesis on growth
cites work: Mathematical modelling of flow in 2D and 3D vascular networks: Applications to anti-angio\-genic and chemotherapeutic drug strategies
cites work: A cellular automaton model for tumour growth in inhomogeneous environment
cites work: A computational framework to assess the efficacy of cytotoxic molecules and vascular disrupting agents against solid tumours
cites work: A mathematical model of HiF-\(1{\alpha}\)-mediated response to hypoxia on the G1/S transition
cites work: Mathematical modelling of the influence of blood rheological properties upon adaptative tu\-mour-induced angiogenesis
Recommended article: Generating patient-specific virtual tumor populations with reaction-diffusion models and molecular imaging data
Recommended article: A patient-specific in vivo tumor model
Recommended article: Recent progress in 3-D computer simulation of tumor growth and treatment
Recommended article: Towards the virtual tumor for optimizing radiotherapy treatments of hypoxic tumors: a novel model of heterogeneous tissue vasculature and oxygenation
Recommended article: Q3436997
Recommended article: Full-scale, three-dimensional simulation of early-stage tumor growth: the onset of malignancy
description: scientific article; zbMATH DE number 6759169