An optimal control strategy for antiretroviral treatment of HIV infection in presence of immunotherapy
This paper proposes and presents a stability analysis of an HIV infection model incorporating the effects of antiretroviral drugs and immunotherapy. The authors study an optimal control problem to maximize healthy CD4+ T cells with minimum cost and side effects of drugs. By using discretization and large-scale optimization methods, they obtain optimal treatment strategies for antiretroviral drugs and immune boosting drugs.
scientific article; zbMATH DE number 7489695
scientific article