Partial differential equations of chemotaxis and angiogenesis
type: Item
instance of: scholarly article
title: Partial differential equations of chemotaxis and angiogenesis
zbMATH Open document ID: 0990.35014
author: B. D. Sleeman
author: Howard A. Levine
published in: Mathematical Methods in the Applied Sciences
publication date: 2002-08-15T00:00:00Z
Mathematics Subject Classification ID: 35B05
Mathematics Subject Classification ID: 92C17
Mathematics Subject Classification ID: 60K35
Mathematics Subject Classification ID: 92C50
zbMATH DE Number: 1618749
zbMATH Keywords: no-flux boundary conditions
zbMATH Keywords: reinforced random walks
zbMATH Keywords: exact solutions
zbMATH Keywords: finite time collapse
zbMATH Keywords: blow-up
zbMATH Keywords: travelling wave
zbMATH Keywords: similarity solutions
MaRDI profile type: Publication
full work available at URL: mma.212
OpenAlex ID: W2089692468
cites work: Initiation of slime mold aggregation viewed as an instability
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cites work: Finite time blow-up in some models of chemotaxis
DOI: 10.1002/MMA.212
review text: In this paper the authors motivate the study of the PDE system NEWLINE\[NEWLINE {\partial P\over \partial t} = D \nabla \cdot (P \nabla (\ln (P/\Phi(\omega)))), NEWLINE\]NEWLINE NEWLINE\[NEWLINE {\partial\omega \over \partial t} = {\mathbf F}(P,\omega), NEWLINE\]NEWLINE and examine some of its properties. Here \(x \in \Omega \subset \mathbb{R}^n\), \(t > 0\), \(D>0\), and the system is supplemented with appropriate initial and no-flux boundary conditions. \(P\) is a population density and \(\omega\) is an \(m\)-dimensional vector of control parameters. NEWLINENEWLINENEWLINEThe main applications of the system above, described in Section 1 of the paper, are in the modelling of chemotaxis, in which case \(P(x,t)\) is typically the density of myxobacteria cells and \(\omega\) is the concentration of the chemotactic signal produced by and reacted to by the bacteria. Alternatively, in a model of tumour angiogenesis, \(P(x,t)\) stands for the density of endothelial cells, in which case \(\omega\) has at least two components, the concentration of tumour angiogenesis factor(s) and of fibronectin. NEWLINENEWLINENEWLINEIn Section 2 the authors review the theory of reinforced random walks and, by passing to a continuum limit, derive from the master equations the above PDEs. This section is best read in conjunction with the work of \textit{H. G. Othmer} and \textit{A. Stevens} [SIAM J. Appl. Math. 57, 1044-1081 (1997; Zbl 0990.35128)]. After a survey of numerical simulations in Section 3, the authors consider in Section 4 exact solutions of the system for the case of \(\Omega\) being one-dimensional, \(\omega\) scalar, and particular choices of \(\Phi(\omega)\) and \({\mathbf F}\). A wealth of phenomena including finite time collapse and blow-up is discovered. In Section 5 the authors survey results on aggregation following \textit{H. A. Levine} and \textit{B. D. Sleeman} [SIAM J. Appl. Math. 57, 683-730 (1997; Zbl 0874.35047)]. In Section 6 existence of travelling wave and othe…
description: scientific article; zbMATH DE number 1618749