Voxel scale complex networks of functional connectivity in the rat brain: neurochemical state dependence of global and local topological properties
type: Item
instance of: scholarly article
title: Voxel scale complex networks of functional connectivity in the rat brain: neurochemical state dependence of global and local topological properties
zbMATH Open document ID: 1401.92133
DOI: 10.1155/2012/615709
author: Adam J. Schwarz
author: Alessandro Gozzi
author: Alessandro Chessa
author: Angelo Bifone
published in: Computational \& Mathematical Methods in Medicine
publication date: 2012-10-10T00:00:00Z
review text: Summary: Network analysis of functional imaging data reveals emergent features of the brain as a function of its topological properties. However, the brain is not a homogeneous network, and the dependence of functional connectivity parameters on neuroanatomical substrate and parcellation scale is a key issue. Moreover, the extent to which these topological properties depend on underlying neurochemical changes remains unclear. In the present study, we investigated both global statistical properties and the local, voxel-scale distribution of connectivity parameters of the rat brain. Different neurotransmitter systems were stimulated by pharmacological challenge (d-amphetamine, fluoxetine, and nicotine) to discriminate between stimulus-specific functional connectivity and more general features of the rat brain architecture. Although global connectivity parameters were similar, mapping of local connectivity parameters at high spatial resolution revealed strong neuroanatomical dependence of functional connectivity in the rat brain, with clear differentiation between the neocortex and older brain regions. Localized foci of high functional connectivity independent of drug challenge were found in the sensorimotor cortices, consistent with the high neuronal connectivity in these regions. Conversely, the topological properties and node roles in subcortical regions varied with neurochemical state and were dependent on the specific dynamics of the different functional processes elicited.
Mathematics Subject Classification ID: 92C55
Mathematics Subject Classification ID: 92C20
Mathematics Subject Classification ID: 05C82
Mathematics Subject Classification ID: 62P10
zbMATH DE Number: 6092375
zbMATH Keywords: global statistical properties
zbMATH Keywords: voxel-scale distribution of connectivity
zbMATH Keywords: rat brain
zbMATH Keywords: local connectivity parameters
zbMATH Keywords: global connectivity parameters
Wikidata QID: Q41916669
describes a project that uses: Brain Connectivity Toolbox
MaRDI profile type: Publication
full work available at URL: https://doi.org/10.1155/2012/615709
OpenAlex ID: W2125389269
cites work: Exploring complex networks
cites work: Collective dynamics of ‘small-world’ networks
cites work: Harmony in the small-world
description: scientific article; zbMATH DE number 6092375