Multiscale estimation of cell kinetics
type: Item
instance of: scholarly article
title: Multiscale estimation of cell kinetics
zbMATH Open document ID: 1203.92023
DOI: 10.1080/17486700903535922
author: Larry W. Jean
author: Martin T. Suchorolski
author: Jihyoun Jeon
author: E. G. Luebeck
published in: Computational \& Mathematical Methods in Medicine
publication date: 2010-12-30T00:00:00Z
full work available at URL: https://eudml.org/doc/226274
review text: Summary: We introduce a methodology based on the \textit{S. E. Luria} and \textit{M. Delbrück} [Genetics 28, 491--511 (1943)] fluctuation model for estimating the cell kinetics of clonally expanding populations. In particular, this approach allows estimation of the net cell proliferation rate, the extinction coefficient and the initial (viable) population size. We present a systematic approach based on spatial partitioning, which captures the local fluctuations of the number and sizes of individual clones. However, partitioning introduces measurement error by inflating the number of clones, which is dependent on time and the degree of cell migration. We perform various in silico experiments to explore the properties of the estimators and we show that there exists a direct relationship between precision and observation time. We also explore the trade-off between the measurement error and the estimation accuracy. By exploring different scales of cellular fluctuations, from the entire population down to those of individual clones, we show that this methodology is useful for inferring important parameters in neoplastic progression.
Mathematics Subject Classification ID: 92C37
Mathematics Subject Classification ID: 62P10
Mathematics Subject Classification ID: 60G99
zbMATH DE Number: 5830396
Wikidata QID: Q39573801
MaRDI profile type: Publication
OpenAlex ID: W2118778037
DBLP publication ID: journals/cmmm/JeanSJL10
description: scientific article; zbMATH DE number 5830396