Evolutionary game between commensal and pathogenic microbes in intestinal microbiota
type: Item
instance of: scholarly article
title: Evolutionary game between commensal and pathogenic microbes in intestinal microbiota
zbMATH Open document ID: 1395.92090
author: D. Kharzeev
published in: Games
publication date: 2018-08-01T00:00:00Z
review text: Summary: The human intestinal microbiota plays a fundamental role in host health and is associated with many diseases when the homeostasis is disturbed. Although recent achievements in metagenomic sequencing have begun to reveal the variety of microbial composition associated with healthy and disease states, species-specific interactions and systematic dynamics still pose a great challenge to resolve the complexity of human microbiota. Using Clostridium difficile infection in human intestinal microbiota as an example, we apply evolutionary game theory to gain a fundamental understanding of the phenotypic variability and dynamic progression of microbiota. Here, microbiota dynamics are determined by the frequency-dependent fitness of each phenotypic population in the presence of the others. More specifically, the fitness is a function of phenotypic composition of the microbiota. We show how the phenotypic variability of microbiota can be explained by game theoretical approach. Knowledge of this study provides a new perspective in administrating antibiotic when dealing with pathogenic invasion. Instead of solely targeting to pathogens, therapies should aim at the whole ecosystem by reducing the fitness of pathogens compared to that of commensal microbes. In this case, the system will eradicate the pathogens by itself.
Mathematics Subject Classification ID: 92C50
Mathematics Subject Classification ID: 91A22
Mathematics Subject Classification ID: 92C42
zbMATH DE Number: 6911959
zbMATH Keywords: evolutionary game theory
zbMATH Keywords: microbiota
zbMATH Keywords: commensal bacteria
zbMATH Keywords: pathogenic bacteria
MaRDI profile type: Publication
full work available at URL: g7030026
OpenAlex ID: W2520987202
cites work: Q3040961
cites work: Evolutionary Games and Population Dynamics
DOI: 10.3390/G7030026
description: scientific article; zbMATH DE number 6911959