Experimental determination and mathematical model of the transient incorporation of cholesterol in the arterial wall
type: Item
instance of: scholarly article
title: Experimental determination and mathematical model of the transient incorporation of cholesterol in the arterial wall
zbMATH Open document ID: 0707.92011
DOI: 10.1007/BF02460805
author: S. Neumann
author: Scott A. Berceli
author: Eva M. Sevick
author: A. Michael Lincoff
author: ViJay S. Warty
author: Arthur M. Brant
author: Ira M. Herman
author: Harvey S. Borovetz
published in: Bulletin of Mathematical Biology
publication date: 1990-01-01T00:00:00Z
review text: Experimental data of the radial incorporation of labeled cholesterol \([^{14}C-4]\) into the artery wall is regressed against a mathematical model that predicts macromolecular transport in this biological system. Data is obtained using excised canine carotid arteries that are perfused in vitro under pulsatile hemodynamic conditions for 2 hr. Vessels are exposed to either normotensive hemodynamics, hypertensive hemodynamics, or simulations in which the rate of flow or vessel compliance is deliberately altered. Several arteries are studied under normotensive conditions following balloon catheter deendothelialization. Results of this experimental investigation support our hypothesis that hemodynamics and the endothelial lining influence wall flux in intact vessels. Based upon our companion measurements of vessel wall forces and endothelial cellular morphology accompanying hemodynamic simulations, we suggest that hemodynamically induced alterations to endothelial structures lead to the increased permeability, convection and incorporation that we observe in this work.
Mathematics Subject Classification ID: 92C50
Mathematics Subject Classification ID: 92C30
zbMATH DE Number: 4162706
zbMATH Keywords: atherosclerosis
zbMATH Keywords: radial incorporation of labeled cholesterol
zbMATH Keywords: artery wall
zbMATH Keywords: macromolecular transport
zbMATH Keywords: excised canine carotid arteries
zbMATH Keywords: pulsatile hemodynamic conditions
zbMATH Keywords: hemodynamics
zbMATH Keywords: vessel wall forces
zbMATH Keywords: endothelial cellular morphology
zbMATH Keywords: permeability
zbMATH Keywords: convection
Wikidata QID: Q41219295
MaRDI profile type: Publication
cites work: Q5591849
cites work: Q3916429
cites work: An Algorithm for Least-Squares Estimation of Nonlinear Parameters
cites work: Transport of macromolecules in arterial wall in vivo: A mathematical model and analytical solutions
full work available at URL: https://doi.org/10.1007/bf02460805
OpenAlex ID: W2009523906
description: scientific article; zbMATH DE number 4162706