A variational approach to optimal two-stage designs

DOI10.1002/SIM.8291zbMATH Open1545.62502MaRDI QIDQ6625214

Kevin Kunzmann, C. Herrmann, Meinhard Kieser, Maximilian Pilz, Geraldine Rauch

Publication date: 28 October 2024

Published in: Statistics in Medicine (Search for Journal in Brave)

zbMATH Keywords

clinical trialoptimal designadaptive designsample size calculationinverse normal combination test

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10)

Cites Work

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Related Items (10)

Point estimation, confidence intervals, and \(P\)-values for optimal adaptive two-stage designs with normal endpoints ⋮ Beta spending function based on conditional power in group sequential design ⋮ Conditional power and friends: the why and how of (un)planned, unblinded sample size recalculations in confirmatory trials ⋮ Authors' reply to ``Comments on `Adaptive sample size modification in clinical trials: Start small then ask for more?{'} ⋮ Comments on ``Adaptive sample size modification in clinical trials: start small then ask for more? ⋮ A new conditional performance score for the evaluation of adaptive group sequential designs with sample size recalculation ⋮ Optimal planning of adaptive two-stage designs ⋮ Optimal adaptive promising zone designs ⋮ Optimization of the two-stage group sequential three-arm gold-standard design for non-inferiority trials ⋮ New results on optimal conditional error functions for adaptive two-stage designs

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